Pentobarbital will minimize the level or effect of levamlodipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. pentobarbital will reduce the level or influence of nicardipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. pentobarbital will decrease the extent or effect of buprenorphine by affecting hepatic/intestinal enzyme CYP3A4 metabol... https://joshuao888jxk4.wikicorrespondent.com/user