Metabolism: Oxycodone hydrochloride is thoroughly metabolized to noroxycodone, oxymorphone, as well as their glucuronides. The main circulating metabolite is noroxycodone with an AUC ratio of 0. Actual physical dependence is manifested by withdrawal signs and symptoms following abrupt discontinuation of a drug or on administration of the antagonist. Physical dependence https://morfin30mg60369.thezenweb.com/5-simple-statements-about-oxycodone-20-mg-depot-explained-73097259